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Publications of the Bf3R
The scientists of the German Center for the Protection of Laboratory Animals (Bf3R) regularly publish the results of their scientific work in form of peer-reviewed articles in journals or on document servers for preprints, in form of conference publications, as book chapters and patents.
Here you will find a list of Bf3R publications since 2015, sorted by year of publication:
2024:
Drude, N., Nagel-Riedasch, S., Rosshart, S. P., Diefenbach, A., Diederich, K., Duerr, C. U., Harms, C., Heppner, F., Kolesnichenko, M., Lewejohann, L., Mall, M. A., Müller, D., Opitz, B., Rosshart, S. P., Schönfelder, G., Tölch, U., Willimsky, G. and Jordan, S. (2024). "A facility for laboratory mice with a natural microbiome at Charité – Universitätsmedizin Berlin". Lab animal : information, ideas, methods and materials for the animal research professional
https://doi.org/10.1038/s41684-024-01474-4
Atter, A., Ofori, H., Akonor, P. T., Andoh-Odoom, A., Ampah, J., Owusu, M., Peget, F., Overå, R., Kolding, J., Pucher, J. and Kjellevold, M. (2024). Enriched local convenience foods with two different small pelagic fish species increases the nutritional value without compromising taste. International Journal of Gastronomy and Food Science 37(-):100956.
http://dx.doi.org/https://doi.org/10.1016/j.ijgfs.2024.100956
Becker, P. C., Güth-Steffens, M., Lazarow, K., Sonntag, N., Braun, D., Masfaka, I., Renko, K., Schomburg, L., Köhrle, J., von Kries, J. P., Schweizer, U., Krause, G., Protze, P. (2024). Identification of Human TRIAC Transmembrane Transporters. Thyroid 34(7):920-930
https://doi.org/10.1089/thy.2023.0592
Bredow, C., Thery, F., Wirth, E. K., Kespohl, M., Kleinau, G., Kelm, N., Gimber, N., Schmoranzer, J., Voss, M., Klingel, K., Spranger, J., Renko, K., Ralser, M., Mülleder, M., Heuser, A., Knobeloch, K.-P., Scheerer, P., Kirwan, J., Brüning, U., Berndt, N., Impens, F. and Beling, A. (2024). ISG15 blocks cardiac glycolysis and ensures sufficient mitochondrial energy production during Coxsackievirus B3 infection. Cardiovascular Research.
http://dx.doi.org/10.1093/cvr/cvae026
Butzke, D., Bert, B., Gulich, K., Schönfelder, G. and Neves, M. (preprint). SMAFIRA: a literature-based web tool to assist researchers with retrieval of 3R-relevant information. Laboratory Animals.
http://dx.doi.org/10.1177/00236772241237608
Canbolat, P., Wilzopolski, J., Kaessmeyer, S., Filor, V., Vidak, J., Rüger, M., Mägert, H.-J., Forssmann, W.-G. and Bäumer, W. (2024). LEKTI domain 6 displays anti-inflammatory action in vitro and in a murine atopic dermatitis model. Journal of Dermatological Science 115(1):13-20.
http://dx.doi.org/10.1016/j.jdermsci.2024.03.004
Diederich, K., Steinfath, M., Bannach-Brown, A., Bert, B., Butzke, D., Wildner, P. L., Wurm, M., Schadock, I. and Heinl, C. (2024). Protocol for the systematic review of age and sex in preclinical models of age-correlated diseases. F1000Research 13(-)
https://doi.org/10.12688/f1000research.153466.1
Gerhardt, P., Begall, S., Frädrich, C., Renko, K., Heinrich, A., Köhrle, J. and Henning, Y. (2024). Low thyroxine serves as an upstream regulator of ecophysiological adaptations in Ansell’s mole-rats. Frontiers in Endocrinology.
https://doi.org/10.3389/fendo.2024.1329083
Hohlbaum, K., Andresen, N., Mieske, P., Kahnau, P., Lang, B., Diederich, K., Palme, R., Mundhenk, L., Sprekeler, H., Hellwich, O., Thöne-Reineke, C. and Lewejohann, L. (2024). Lockbox enrichment facilitates manipulative and cognitive activities for mice [version 2; peer review: 2 approved]. Open Research Europe 4(-):108
https://doi.org/10.12688/openreseurope.17624.2
Hohlbaum, K., Merle, R., Warnke, R., Nagel-Riedasch, S., Thöne-Reineke, C. and Ullmann, K. (online first 2023). The implementation of tunnel handling in a mouse breeding facility revealed strain-specific behavioural responses. Laboratory Animals 0(0):1-13
https://doi.org/10.1177/00236772231215077
Jo, S., Park, S. B., Kim, H., Im, I., Noh, H., Kim, E.-M., Kim, K. Y., Oelgeschlaeger, M., Kim, J.-H. and Park, H.-J. (2024). hiPSC-derived macrophages improve drug sensitivity and selectivity in a macrophage-incorporating organoid culture model. Biofabrication.
http://dx.doi.org/10.1088/1758-5090/ad4c0a
Kadic, A., Oles, P., Fischer, B. C., Reetz, A. E., Sylla, B.S., Feiertag, K., Ritz, V., Heise, T., Marx-Stölting, P., Tralau, T., Renko, K. and Solano, M. d. L. M. (2024). In vitro and in vivo investigation of a thyroid hormone system-specific interaction with triazoles. Scientific Reports.
https://doi.org/10.1038/s41598-024-55019-3
Kim, H., Kim, S. K., Oelgeschläger, M. and Park, H.-J. (2024). Prediction of Acute Hepatotoxicity With Human Pluripotent Stem Cell-Derived Hepatic Organoids. Current Protocols 4(4):e1015.
http://dx.doi.org/10.1002/cpz1.1015
Kitsara, M., Smajlhodži?-Deljo, M., Gurbeta Pokvic, L., Bert, B., Bubalo, N., Erden, S., Franco, N. H., Chirico, G., Gómez Raja, J., Gonzalez-Uarquin, F., Lang, A., Linklater, N., Mojsova, S., Olsson, I. A. S., Sandvig, I., Schaffert, A., Schmit, M., Schober, S., Sevastre, B., Wilflingseder, D., Ahluwalia, A. and Neuhaus, W. (2024). Introduction of the COST Action IMPROVE on Improving the Quality of Biomedical Science with 3Rs Concepts ATLA (Alternatives to Laboratory Animals) 52(6):326-333
https://doi.org/10.1177/02611929241286024
Lauwereyns, J., Bajramovic, J., Bert, B., Camenzind, S., De Kock, J., Elezovi?, A., Erden, S., Gonzalez-Uarquin, F., Ulman, Y. I., Hoffmann, O. I., Kitsara, M., Kostomitsopoulos, N., Neuhaus, W., Petit-Demouliere, B., Pollo, S., Riso, B., Schober, S., Sotiropoulos, A., Thomas, A., Vitale, A., Wilflingseder, D. and Ahluwalia, A. (2024). "Toward a common interpretation of the 3Rs principles in animal research". Lab animal 2024
https://doi.org/10.1038/s41684-024-01476-2
Li, Y., Deng, D., Höfer, C. T., Kim, J., Heo, W. D., Xu, Q., Liu, X. and Zi, Z. (2024). Liebig’s law of the minimum in the TGF-β pathway. Nature Structural & Molecular Biology.
https://doi.org/10.1101/2023.07.10.548398
Neves, M. (preprint). Detection of fields of applications in biomedical abstracts with the support of argumentation elements. arXiv.
http://dx.doi.org/10.48550/arXiv.2404.06121
Odje, F., Meijer, D., Von Coburg, E., Van der Hooft, J. J. J., Dunst, S., Medema, M. H. and Volkamer, A. (2024). Unleashing the potential of cell painting assays for compound activities and hazards prediction. Frontiers in Toxicology 6(-):1401036
https://doi.org/10.3389/ftox.2024.1401036
Ohnesorge, N., Wilzopolski, J., Steinfath, M., Lewejohann, L., Banneke, S., Heinl, C. (Preprint) Assessment of the effect of tricaine (MS-222)-induced anesthesia on brain-wide neuronal activity of zebrafish (Danio rerio) larvae. Front. Neurosci., 24 September 2024, Sec. Neuropharmacology, Volume 18 - 2024
https://doi.org/10.3389/fnins.2024.1456322
Pederson, C., Vogliano, C., Sadoff, C., D’Cruz, G., Kennedy, G., White, G., Alleway, H., Kim, J. K., Pucher, J., Koome, K., Geagan, K., Chang, K., Mbuya, M., Sumaila, R., Thilsted, S., Palmer, S., Oenema, S., Zimpita, T., Agostini, V. and Battista, W. (2024). Regenerative Aquatic Foods Roadmap.
https://www.aquaculturescience.org/content/dam/tnc/nature/en/documents/RegenerativeAquaticFoodsRoadmap.pdf
Pont, C., Sampietro, A., Pérez-Areales, F. J., Cristiano, N., Albalat, A., Pérez, B., Bartolini, M., De Simone, A., Andrisano, V., Barenys, M., Teixidó, E., Sabaté, R., Loza, M. I., Brea, J. and Muñoz-Torrero, D. (2024). Stepwise Structural Simplification of the Dihydroxyanthraquinone Moiety of a Multitarget Rhein-Based Anti-Alzheimer Lead to Improve Drug Metabolism and Pharmacokinetic Properties. Pharmaceutics 16(8):982
https://doi.org/10.3390/pharmaceutics16080982
Schlegel, L., Kleine, A. S., Doherr, M. G. and Fischer-Tenhagen, C. (2024). How to see stress in chickens: On the way to a Stressed Chicken Scale. Poultry Science 103(8).
http://dx.doi.org/10.1016/j.psj.2024.103875
Wagenaars, F., Cenijn, P., Scholze, M., Frädrich, C., Renko, K., Köhrle, J. and Hamers, T. (Online ahead of print). Screening for endocrine disrupting chemicals inhibiting monocarboxylate 8 (MCT8) facilitated thyroid hormone transport using a modified nonradioactive assay. Toxicology in vitro 96.
http://dx.doi.org/10.1016/j.tiv.2023.105770
Wilhelmi, P., Haake, V., Zickgraf, F. M., Giri, V., Ternes, P., Driemert, P., Nöth, J., Scholz, S., Barenys Espadaler, M., Flick, B., Birk, B., Kamp, H., Landsiedel, R. and Funk-Weyer, D. (2024). Molecular signatures of angiogenesis inhibitors: a single-embryo untargeted metabolomics approach in zebrafish. Archives of Toxicology 98(-):943-956
https://doi.org/10.1007/s00204-023-03655-5
Vogliano, C., Kennedy, G., Alleway, H., Sadoff, C., D’Cruz, G., White, G., Kim, J. K., Pucher, J., Koome, K., Geagan, K., Chang, K., Mbuya, M., Thilsted, S., Palmer, S., Sumaila, U. R. and Battista, W. (2024). Regenerative aquatic foods can be a win-win for human and planetary health. Nature Food 5(-):718–719
https://doi.org/10.1038/s43016-024-01043-5
2023:
SCHEER (Scientific Committee on Health, Environmental and Emerging Risks), Opinion on the Revision of Annexes III and IV of Directive 2010/63/EU on the protection of animals used for scientific purposes regarding accommodation parameters and methods of killing for zebrafish, and accommodation parameters for Passerine birds, adopted on 25 September 2023
https://health.ec.europa.eu/publications/scheer-revision-annexes-iii-and-iv-directive-201063eu-protection-animals-used-scientific-purposes_en
Audebert, M., Assmann, A.-S., Azqueta, A., Babica, P., Benfenati, E., Bortoli, S., Bouwman, P., Braeuning, A., Burgdorf, T., Coumoul, X., Debizet, K., Dusinska, M., Ertych, N., Fahrer, J., Fetz, V., Le Hegarat, L., Lopez de Cerain, A., Heusinkveld, H. J., Hogeveen, K., Jacobs, M. N., Luijten, M., Raitano, G., Recoules, C., Runden-Pran, E., Saleh, M., Sovadinova, I., Stampar, M., Thibol, L., Tomkiewicz, C., Vettorazzi, A., Van de Water, B., El Yamani, N., Zegura, B. and Oelgeschläger, M. (2023). New approach methodologies to facilitate and improve the hazard assessment of non-genotoxic carcinogens-a PARC project. Frontiers in Toxicology 5:1220998. http://dx.doi.org/10.3389/ftox.2023.1220998
Brandwein, C., Leenaars, C. H. C., Becker, L., Pfeiffer, N., Iorgu, A.-M., Hahn, M., Vairani, G. A., Lewejohann, L., Bleich, A., Mallien, A. S. and Gass, P. (2023). A systematic mapping review of the evolution of the rat Forced Swim Test: Protocols and outcome parameters. Pharmacological Research 196:106917. http://dx.doi.org/10.1016/j.phrs.2023.106917
Dolokov, A., Andersen, N., Hohlbaum, K., Thöne-Reineke, C., Lewejohann, L., Hellwich, O. (2023) Upper bound tracker: a multi-animal tracking solution for closed laboratory settings. Scitepress, 4, 945–952. https://dx.doi.org/10.5220/0011609500003417
Engel, A. M., El-Khatib, A. H., Klevenhusen, F., Weiss, M., Aboling, S., Sachse, B., Schäfer, B., Weigel, S., Pieper, R. and Fischer-Tenhagen, C. (2023). Detection of Hypoglycin A and MCPrG Metabolites in the Milk and Urine of Pasture Dairy Cows after Intake of Sycamore Seedlings. Journal of agricultural and food chemistry 71:10751-10760. http://dx.doi.org/https://doi.org/10.1021/acs.jafc.3c01248
Fischer-Tenhagen, C., Bohm, D., Finnah, A., Arlt, S., Schlesinger, S., Borchardt, S., Sutter, F., Tippenhauer, C. M., Heuwieser, W. and Venjakob, P. L. (2023). Residue Concentrations of Cloxacillin in Milk after Intramammary Dry Cow Treatment Considering Dry Period Length. Animals 13(16):2558. http://dx.doi.org/https://doi.org/10.3390/ani13162558
GarridoGamarro, E., Svanevik, C. S., Lundebye, A.-K., Sanden, M., D’Agostino, E., Kjellevold, M., Pincus, L. and Pucher, J. (2023). Challenges in the Implementation of Food Safety and Quality Assurance Systems in Small-Scale Fisheries. Food Quality and Safety, 7, 1-9. http://dx.doi.org/10.1093/fqsafe/fyad007
Gerhardt, P., Begall, S., Frädrich, C., Renko, K., Hildebrandt, T. B., Holtze, S., Heinrich, A., Sahm, A., Meci, X., Köhrle, J., Rijntjes, E. and Henning, Y. (2023). Comparative analysis of thyroid hormone systems in rodents with subterranean lifestyle. Scientific Reports 13, 3122. http://dx.doi.org/10.1038/s41598-023-30179-w
Hackler, J., Demircan, K., Chillon, T. S., Sun, Q., Geisler, N., Schupp, M., Renko, K., Schomburg, L. (2023) High throughput drug screening identifies resveratrol as suppressor of hepatic SELENOP expression. Redox Biology, 2023 Feb; 59: 102592. https://doi.org/10.1016/j.redox.2022.102592
Hobbiesiefken, U., Urmersbach, B., Jaap, A., Diederich, K. and Lewejohann, L. (2023). Rating enrichment items by female group-housed laboratory mice in multiple binary choice tests using an RFID-based tracking system. PLoS One 18 (1), e0278709. http://dx.doi.org/10.1371/journal.pone.0278709
Kahnau, P., Jaap, A., Diederich, K., Gygax, L., Rudeck, J. and Lewejohann, L. (2023). Determining the value of preferred goods based on consumer demand in a home-cage based test for mice. Behavior Research Methods 55 (2), 751-766. http://dx.doi.org/10.3758/s13428-022-01813-8
Kahnau, P., Jaap, A., Urmersbach, B., Diederich, K. and Lewejohann, L. (2022). Development of an IntelliCage-based cognitive bias test for mice. Open Research Europe. http://dx.doi.org/https://doi.org/10.12688/openreseurope.15294.1
Knipper, A.-D., Göhlich, S., Stingl, K., Ghoreishi, N., Fischer-Tenhagen, C., Bandick, N., Tenhagen, B.-A. and Crease, T. (2023). Longitudinal Study for the Detection and Quantification of Campylobacter spp. in Dairy Cows during Milking and in the Dairy Farm Environment. Foods 12(8). http://dx.doi.org/https://doi.org/10.3390/foods12081639
Koch, F., Pieper, R. and Fischer-Tenhagen, C. (2023). Messung der Körpertemperatur beim Schwein: Können Infrarotthermometer eine Alternative sein?. Tierärztliche Praxis: Ausgabe Großtiere / Nutztiere 51(02):84-92. http://dx.doi.org/10.1055/a-2046-5061
Körber, N. (2023) MIA is an open-source standalone deep learning application for microscopic image analysis. Cell Reports Methods, 26 June 2023. https://doi.org/10.1016/j.crmeth.2023.100517
Kühne, B. A., Gutierrez-Vázquez, L., Sánchez Lamelas, E., Guardia-Escote, L., Pla, L., Loreiro, C., VGratacós, E., Barenys, M. and Illa, M. (2023). Lactoferrin/sialic acid prevents adverse effects of intrauterine growth restriction on neurite length: investigations in an in vitro rabbit neurosphere model. Frontiers in Celular Neuroscience 17. http://dx.doi.org/https://doi.org/10.3389/fncel.2023.1116405
Lang, B., Kahnau, P., Hohlbaum , K., Mieske, P., Andresen, N. P., Boon, M. N., Thöne-Reineke, C., Lewejohann, L. and Diederich, K. (2023). Challenges and advanced concepts for the assessment of learning and memory function in mice. Frontiers in Behavioral Neuroscience 17:1230082. http://dx.doi.org/https://doi.org/10.3389/fnbeh.2023.1230082
Mieske, P., Scheinpflug, J., Yorgan, T. A., Brylka, L., Palme, R., Hobbiesiefken, U., Preikschat, J., Lewejohann, L. and Diederich, K. (2023). Effects of more natural housing conditions on the muscular and skeletal characteristics of female C57BL/6J mice. Laboratory Animal Research 39:9. http://dx.doi.org/10.1186/s42826-023-00160-9
Mills, D. J., Simmance, F., Byrd, K., Ahern, M., Cohen, P., D’Agostino, E., Fiorella, K., Garrido-Gamarro., E., Gondwe, E., Hicks, C., Kaunda, E., Kjellevold, M., Kolding, J., Levsen, A., Lundebye, A. K., Marinda, P., McNeil, A., Nagoli, J., Nankwenya, B., Nico, G., O’Meara, L., Pincus, L., Pucher, J., J., R., Roscher, M., Sanden, M., Seow, T. K., Svanevik, C., Teoh, S. J., Thilsted, S., Tilley, A. and Tuazon, M. A. (2023). Contributions of small-scale fisheries to food security and nutrition. Illuminating Hidden Harvests. 145-174. https://www.fao.org/3/cc4576en/cc4576en.pdf
Neves, M., Klippert, A., Knöspel, F., Rudeck, J., Stolz, A., Ban, Z., Becker, M., Diederich, K., Grune, B., Kahnau, P., Ohnesorge, N., Pucher, J., Schönfelder, G., Bert, B. and Butzke, D. (2023). Automatic classification of experimental models in biomedical literature to support searching for alternative methods to animal experiments. Journal of Biomedical Semantics 14(13). http://dx.doi.org/https://doi.org/10.1186/s13326-023-00292-w
Ramhoj, L., Axelstad, M., Baert, Y., Canas-Portilla, A., Chalmel, F., Dahmen, L., de la Vieja, A., Evrard, B., Haigis, A.C., Hamers, T., Heikamp, K., Holbech, H., Iglesias-Hernandez, P., Knapen, D., Marchandise, L., Morthorst, J.E., Nikolov, N.G., Nissen, A.C.V.E., Oelgeschlaeger, M., Renko, K., Rogiers, V., Schüürmann, G., Stinckens, E., Stub, M.H., Torres-Ruiz, M., Van Duursen, M., Vanhaecke, T., Vergauwen, L., Wedebye, E.B., Svingen, T. (2023) New approach methods to improve human health risk assessment of thyroid hormone system disruption–a PARC project. Frontiers Toxicology, 17 May 2023.
https://doi.org/10.3389/ftox.2023.1189303
Romero, N. G., Gutierrez, G., Teixido, E., Li, L., Klose, J., Leung, P. C., Cañigueral, S., Fritsche, E. and Barenys, M. (2023). Developmental neurotoxicity evaluation of three Chinese herbal medicines in zebrafish larvae by means of two behavioral assays: touch-evoked response and light/dark transition. Reproductive Toxicology 121:108469. http://dx.doi.org/https://doi.org/10.1016/j.reprotox.2023.108469
Scheinpflug, J., Höfer, C. T., Schmerbeck, S. S., Steinfath, M., Doka, J., Afework Tesfahunegn, Y., Violet, N., Renko, K., Gulich, K., John, T., Schneider, M. R., Wistorf, E., Schönfelder, G., Schulze, F. (2023) A microphysiological system for studying human bone biology under simultaneous control of oxygen tension and mechanical loading. Lab on a Chip, 2023 July 3. https://doi.org/10.1039/D3LC00154G
Teixidó, E., Riera-Colomer, C., Raldúa, D., Pubill, D., Escubedo, E., Barenys, M. and López-Arnau, R. (2023). First generation synthetic cathinones produce arrhythmia in zebrafish eleutheroembryos. A New Approach Methodology for New Psychoactive Substances cardiotoxicity evaluation. International Journal of Molecular Sciences. http://dx.doi.org/https://doi.org/10.3390/ijms241813869
Uluckan, Ö., Bruno, S., Wang, Y., Wack, N., Wilzopolski, J., Goetschy, J.-F., Delucis-Bronn, C., Urban, B., Fehlmann, D., Stark, H., Hauchard, A., Roussel, E., Kempf, D., Kaupmann, K., Raulf, F., Bäumer, W., Röhn, T. A. and Zerwes, H. G. (2023). Adriforant is a functional antagonist of histamine receptor 4 and attenuates itch and skin inflammation in mice. European Journal of Pharmacology 945, 175533. http://dx.doi.org/10.1016/j.ejphar.2023.175533
Wagenknecht, T., Eusemann, B., Schwedhelm, P., Schönfelder, G. and Bert, B. (2023). Das Vorliegen eines “vernünftigen Grundes” bei der Tötung überzähliger Versuchstiere. Natur und Recht 45, 225–233. https://doi.org/10.1007/s10357-022-4103-8
Wagenknecht, T., Eusemann, B., Schwedhelm, P., Schönfelder, G., Bert, B. (2023) Die Tötung überzähliger Versuchstiere – das Erfordernis des „vernünftigen Grundes“ und die Übertragung aktueller Rechtsprechung auf den Versuchstierbereich. Natur und Recht, Januar 2023, 45, 22-30, https://doi.org/10.1007/s10357-022-4102-9
Weber, A.G., Birk, B., Giri, V., Hoffmann, S., Renko, K., Coecke, S., Schneider, S., Funk-Weyer, D., and Landsiedel, R. (2023) Assessment of the Predictivity of DIO1-SK Assay to Investigate DIO1 Inhibition in Human Liver Microsomes. Applied In Vitro Toxicology, Vol. 9, No. 2, 15 June 2023.
https://doi.org/10.1089/aivt.2022.0016
Wessels, L., Kjellevold, M., Kolding, J., Odoli, C., Aakre, I., Reich, F. and Pucher, J. (2023). Putting small fish on the table: The underutilized potential of small indigenous fish to improve food and nutrition security in East Africa. Food Security. http://dx.doi.org/https://doi.org/10.1007/s12571-023-01362-8
Wewetzer, H., Wagenknecht, T., Bert, B. and Schönfelder, G. (2023). The fate of surplus laboratory animals. EMBO Reports 24, :e56551. http://dx.doi.org/10.15252/embr.202256551
Wilhelmi, P., Giri, V., Zickgraf, F. M., Haake, V., Henkes, S., Driemert, P., Michaelis, P., Busch, W., Scholz, S., Flick, B., Barenys, M., Birk, B., Kamp, H., Landsiedel, R. and Funk-Weyer, D. (2023). A metabolomics approach to reveal the mechanism of developmental toxicity in zebrafish embryos exposed to 6-propyl-2-thiouracil. Chemico-Biological Interactions 382. http://dx.doi.org/https://doi.org/10.1016/j.cbi.2023.110565
Wilzopolski, J., Putrianti, E., Balik, P., Goerlich, S., Lindner, T. and Ohnesorge, N. (2023). Assessment of the antinociceptive efficacy of analgesics, anesthetics and other compounds in zebrafish (Danio rerio). Journal of Veterinary Pharmacology and Therapeutics 46(S1):45-45. http://dx.doi.org/10.1111/jvp.13202
Wolter, A., Bucher, C. H., Kurmies, S., Schreiner, V., Konietschke, F., Hohlbaum, K., Klopfleisch, R., Löhning, M., Thöne-Reineke, C., Buttgereit, F., Huwyler, J., Jirkof, P., Rapp, A. E. and Lang, A. (2023). A buprenorphine depot formulation provides effective sustained post-surgical analgesia for 72 h in mouse femoral fracture models. Scientific Reports 13 (1), 3824. http://dx.doi.org/10.1038/s41598-023-30641-9
2022:
Bühler, M., Fahrländer, J., Sauter, A., Becker, M., Wistorf, E., Steinfath, M. and Stolz, A. (2022). GPER1 links estrogens to centrosome amplification and chromosomal instability in human colon cells. Life Science Alliance, 6 (1), e202201499. http://dx.doi.org/10.26508/lsa.202201499
Bühler, M. & Stolz, A. (2022) Estrogens – Origin of Centrosome Defects in Human cancer? Cells, 11(3), 432. https://doi.org/10.3390/cells11030432
Deng, D. & Zi, Z. (2022). Absolute Quantification of TGF-beta Signaling Proteins Using Quantitative Western Blot. In: Z. Zi and X. Liu. TGF-Beta Signaling. Methods and Protocols. Methods in Molecular Biology, 2488. Humana, New York, NY. 1-12. http://dx.doi.org/10.1007/978-1-0716-2277-3_1
Diederich, K., Schmitt, K., Schwedhelm, P., Bert, B. and Heinl, C. (2022). A guide to open science practices for animal research. PLOS Biology, 20 (9), e3001810. http://dx.doi.org/10.1371/journal.pbio.3001810
Engel, A. M., Klevenhusen, F., Moenning, J.-L., Numata, J., Fischer-Tenhagen, C., Sachse, B., Scha?fer, B., Fry, H., Kappenstein, O. and Pieper, R. (2022). Investigations on the Transfer of Quinolizidine Alkaloids from Lupinus angustifolius into the Milk of Dairy Cows. Journal of Agricultural and Food Chemistry, 70 (37), 11749–11758. http://dx.doi.org/10.1021/acs.jafc.2c02517
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Wistorf, E., Knöspel, F., Schönfelder, G., & Schneider, M. R. (2020). 3R-related research funding: Insights from a meeting hosted by the German Centre for the Protection of Laboratory Animals (Bf3R). ALTEX, 37(2), 320–323. https://doi.org/10.14573/altex.2002201
Wittkowski, P., Violet, N., Oelgeschläger, M., Schönfelder, G., & Vogl, S. (2020). A quantitative medium-throughput assay to measure Caenorhabditis elegans development and reproduction. STAR Protocols, 1(3), 100224. https://doi.org/10.1016/j.xpro.2020.100224
Zhang, X., Xu, Q., Zi, Z., Liu, Z., Wan, C., Crisman, L., Shen, J., & Liu, X. (2020). Programmable Extracellular Vesicles for Macromolecule Delivery and Genome Modifications. Developmental Cell, 55(6), 784-801.e9. https://doi.org/10.1016/j.devcel.2020.11.007
Zouboulis, C. C., Yoshida, G. J., Wu, Y., Xia, L., & Schneider, M. R. (2020). Sebaceous gland: Milestones of 30-year modelling research dedicated to the “brain of the skin”. Experimental Dermatology, 29(11), 1069–1079. https://doi.org/10.1111/exd.14184
2019:
Bawden, R., Bretonnel Cohen, K., Grozea, C., Jimeno Yepes, A., Kittner, M., Krallinger, M., Mah, N., Neveol, A., Neves, M., Soares, F., Siu, A., Verspoor, K., & Vicente Navarro, M. (2019). Findings of the WMT 2019 Biomedical Translation Shared Task: Evaluation for MEDLINE Abstracts and Biomedical Terminologies. Proceedings of the Fourth Conference on Machine Translation (Volume 3: Shared Task Papers, Day 2), 29–53. https://doi.org/10.18653/v1/W19-5403
Bert, B., Heinl, C., Chmielewska, J., Schwarz, F., Grune, B., Hensel, A., Greiner, M., & Schönfelder, G. (2019). Refining animal research: The Animal Study Registry. PLoS Biology, 17(10), e3000463. https://doi.org/10.1371/journal.pbio.3000463
Burgdorf, T., Piersma, A. H., Landsiedel, R., Clewell, R., Kleinstreuer, N., Oelgeschläger, M., Desprez, B., Kienhuis, A., Bos, P., de Vries, R., de Wit, L., Seidle, T., Scheel, J., Schönfelder, G., van Benthem, J., Vinggaard, A. M., Eskes, C., & Ezendam, J. (2019). Workshop on the validation and regulatory acceptance of innovative 3R approaches in regulatory toxicology - Evolution versus revolution. Toxicology in Vitro, 59, 1–11. https://doi.org/10.1016/j.tiv.2019.03.039
Chmielewska, J., Bert, B., Grune, B., & Schönfelder, G. (2019). Rechtliche Aspekte der Anwendung des pharmakologisch wirksamen Stoffs Tamoxifen bei der konditionellen Genausschaltung im Versuchstier Maus. Natur Und Recht, 41(1), 26–32. https://doi.org/10.1007/s10357-018-3457-4
Dunst, S., & Tomancak, P. (2019). Imaging Flies by Fluorescence Microscopy: Principles, Technologies, and Applications. Genetics, 211(1), 15–34. https://doi.org/10.1534/genetics.118.300227
Heberle, A. M., Razquin Navas, P., Langelaar-Makkinje, M., Kasack, K., Sadik, A., Faessler, E., Hahn, U., Marx-Stoelting, P., Opitz, C. A., Sers, C., Heiland, I., Schäuble, S., & Thedieck, K. (2019). The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical manner. Life Science Alliance, 2(2). https://doi.org/10.26508/lsa.201800257
Jirkof, P., Rudeck, J., & Lewejohann, L. (2019). Assessing Affective State in Laboratory Rodents to Promote Animal Welfare-What Is the Progress in Applied Refinement Research? Animals, 9(12). https://doi.org/10.3390/ani9121026
Kelly, L., Goeuriot, L., Suominen, H., Neves, M., Kanoulas, E., Spijker, R., Azzopardi, L., Li, D., Jimmy, Palotti, J., & Zuccon, G. (2019). CLEF eHealth 2019 Evaluation Lab. In L. Azzopardi, B. Stein, N. Fuhr, P. Mayr, C. Hauff, & D. Hiemstra (Eds.), Advances in Information Retrieval (pp. 267–274). Springer International Publishing. https://doi.org/10.1007/978-3-030-15719-7_36
Kelly, L., Suominen, H., Goeuriot, L., Neves, M., Kanoulas, E., Li, D., Azzopardi, L., Spijker, R., Zuccon, G., Scells, H., & Palotti, J. (2019). Overview of the CLEF eHealth Evaluation Lab 2019. In F. Crestani, M. Braschler, J. Savoy, A. Rauber, H. Müller, D. E. Losada, G. Heinatz Bürki, L. Cappellato, & N. Ferro (Eds.), Experimental IR Meets Multilinguality, Multimodality, and Interaction (pp. 322–339). Springer International Publishing. https://doi.org/10.1007/978-3-030-28577-7_26
Knebel, C., Heise, T., Zanger, U. M., Lampen, A., Marx-Stoelting, P., & Braeuning, A. (2019). The azole fungicide tebuconazole affects human CYP1A1 and CYP1A2 expression by an aryl hydrocarbon receptor-dependent pathway. Food and Chemical Toxicology, 123, 481–491. https://doi.org/10.1016/j.fct.2018.11.039
Knöspel, F., Ban, Z., Schönfelder, G., & Schneider, M. R. (2019). Next milestone in understanding early life-blastoids mimic embryogenesis in vitro. Biology of Reproduction, 100(1), 11–12. https://doi.org/10.1093/biolre/ioy182
Mei, J., Banneke, S., Lips, J., Kuffner, M. T. C., Hoffmann, C. J., Dirnagl, U., Endres, M., Harms, C., & Emmrich, J. V. (2019). Refining humane endpoints in mouse models of disease by systematic review and machine learning-based endpoint definition. ALTEX, 36(4), 555–571. https://doi.org/10.14573/altex.1812231
Neves, M., Butzke, D., & Grune, B. (2019). Evaluation of Scientific Elements for Text Similarity in Biomedical Publications. Proceedings of the 6th Workshop on Argument Mining, 124–135. https://doi.org/10.18653/v1/W19-4515
Schulze, F., Schneider, M.R. (2019). Hoffnung oder Humbug? Organ-on-a-chip in der biomedizinischen Forschung und als Alternative zum Tierversuch. Deutsches Tierärzteblatt, 67(10).
Solecki, R., Rauch, M., Gall, A., Buschmann, J., Kellner, R., Kucheryavenko, O., Schmitt, A., Delrue, N., Li, W., Hu, J., Fujiwara, M., Kuwagata, M., Mantovani, A., Makris, S.L., Paumgartten, F., Schönfelder, G., Schneider, S., Vogl, S., Kleinstreuer, N., Schneider, M., Schulze, F., Fritsche, E., Clark, R., Shiota, K., Chahoud, I. (2019) Update of the DevTox data database for harmonized risk assessment and alternative methodologies in developmental toxicology: Report of the 9th Berlin Workshop on Developmental Toxicity. Reprod Toxicol. 89, 124-129. https://doi.org/10.1016/j.reprotox.2019.07.003
Wittkowski, P., Marx-Stoelting, P., Violet, N., Fetz, V., Schwarz, F., Oelgeschläger, M., Schönfelder, G., & Vogl, S. (2019). Caenorhabditis elegans As a Promising Alternative Model for Environmental Chemical Mixture Effect Assessment-A Comparative Study. Environmental Science & Technology, 53(21), 12725–12733. https://doi.org/10.1021/acs.est.9b03266
2018:
Fetz, V., Stauber, R. H., & Knauer, S. K. (2018). Translocation Biosensors-Versatile Tools to Probe Protein Functions in Living Cells. Methods in Molecular Biology (Clifton, N.J.), 1683, 195–210. https://doi.org/10.1007/978-1-4939-7357-6_12
Hilse, K. E., Rupprecht, A., Egerbacher, M., Bardakji, S., Zimmermann, L., Wulczyn, A. E. M. S., & Pohl, E. E. (2018). The Expression of Uncoupling Protein 3 Coincides With the Fatty Acid Oxidation Type of Metabolism in Adult Murine Heart. Frontiers in Physiology, 9, 747. https://doi.org/10.3389/fphys.2018.00747
Knebel, C., Kebben, J., Eberini, I., Palazzolo, L., Hammer, H. S., Süssmuth, R. D., Heise, T., Hessel-Pras, S., Lampen, A., Braeuning, A., & Marx-Stoelting, P. (2018). Propiconazole is an activator of AHR and causes concentration additive effects with an established AHR ligand. Archives of Toxicology, 92(12), 3471–3486. https://doi.org/10.1007/s00204-018-2321-x
Knebel, C., Neeb, J., Zahn, E., Schmidt, F., Carazo, A., Holas, O., Pavek, P., Püschel, G. P., Zanger, U. M., Süssmuth, R., Lampen, A., Marx-Stoelting, P., & Braeuning, A. (2018). Unexpected Effects of Propiconazole, Tebuconazole, and Their Mixture on the Receptors CAR and PXR in Human Liver Cells. Toxicological Sciences, 163(1), 170–181. https://doi.org/10.1093/toxsci/kfy026
Lang, A., Volkamer, A., Behm, L., Röblitz, S., Ehrig, R., Schneider, M., Geris, L., Wichard, J., & Buttgereit, F. (2018). In silico methods - Computational alternatives to animal testing. ALTEX, 35(1), 124–126. https://doi.org/10.14573/altex.1712031
Mei, J., Riedel, N., Grittner, U., Endres, M., Banneke, S., & Emmrich, J. V. (2018). Body temperature measurement in mice during acute illness: implantable temperature transponder versus surface infrared thermometry. Scientific Reports, 8(1), 3526. https://doi.org/10.1038/s41598-018-22020-6
Moussallem, D., Ferreira, T. C., Zampieri, M., Cavalcanti, M. C., Xexéo, G., Neves, M., & Ngomo, A.-C. N. (2018). RDF2PT: Generating Brazilian Portuguese Texts from RDF Data. https://arxiv.org/abs/1802.08150
Neves, M., Butzke, D., Schönfelder, G., & Grune, B. (2018). Bf3R at SemEval-2018 Task 7: Evaluating Two Relation Extraction Tools for Finding Semantic Relations in Biomedical Abstracts. Proceedings of The 12th International Workshop on Semantic Evaluation, 816–820. https://doi.org/10.18653/v1/S18-1130
Neves, M., Jimeno Yepes, A., Névéol, A., Grozea, C., Siu, A., Kittner, M., & Verspoor, K. (2018). Findings of the WMT 2018 Biomedical Translation Shared Task: Evaluation on Medline test sets. Proceedings of the Third Conference on Machine Translation: Shared Task Papers, 324–339. https://doi.org/10.18653/v1/W18-6403
Piersma, A. H., Burgdorf, T., Louekari, K., Desprez, B., Taalman, R., Landsiedel, R., Barroso, J., Rogiers, V., Eskes, C., Oelgeschläger, M., Whelan, M., Braeuning, A., Vinggaard, A. M., Kienhuis, A., van Benthem, J., & Ezendam, J. (2018). Workshop on acceleration of the validation and regulatory acceptance of alternative methods and implementation of testing strategies. Toxicology in Vitro, 50, 62–74. https://doi.org/10.1016/j.tiv.2018.02.018
Rudeck, J., Bert, B., Marx-Stoelting, P., Schönfelder, G., & Vogl, S. (2018). Liver lobe and strain differences in the activity of murine cytochrome P450 enzymes. Toxicology, 404–405, 76–85. https://doi.org/10.1016/j.tox.2018.06.001
Salatzki, J., Foryst-Ludwig, A., Bentele, K., Blumrich, A., Smeir, E., Ban, Z., Brix, S., Grune, J., Beyhoff, N., Klopfleisch, R., Dunst, S., Surma, M. A., Klose, C., Rothe, M., Heinzel, F. R., Krannich, A., Kershaw, E. E., Beule, D., Schulze, P. C., … Kintscher, U. (2018). Adipose tissue ATGL modifies the cardiac lipidome in pressure-overload-induced left ventricular failure. PLoS Genetics, 14(1), e1007171. https://doi.org/10.1371/journal.pgen.1007171
Scheinpflug, J., Pfeiffenberger, M., Damerau, A., Schwarz, F., Textor, M., Lang, A., & Schulze, F. (2018). Journey into Bone Models: A Review. Genes, 9(5). https://doi.org/10.3390/genes9050247
Schneider, M. R., & Pincelli, C. (2018). The 3R approach to experimental dermatology. Experimental Dermatology, 27(5), 441–442. https://doi.org/10.1111/exd.13673
Schneider, M. R., & Zouboulis, C. C. (2018). Primary sebocytes and sebaceous gland cell lines for studying sebaceous lipogenesis and sebaceous gland diseases. Experimental Dermatology, 27(5), 484–488. https://doi.org/10.1111/exd.13513
Steinfath, M., Vogl, S., Violet, N., Schwarz, F., Mielke, H., Selhorst, T., Greiner, M., & Schönfelder, G. (2018). Simple changes of individual studies can improve the reproducibility of the biomedical scientific process as a whole. PLOS ONE, 13(9), e0202762. https://doi.org/10.1371/journal.pone.0202762
Stolz, A., Schönfelder, G., & Schneider, M. R. (2018). Endocrine Disruptors: Adverse Health Effects Mediated by EGFR? Trends in Endocrinology and Metabolism: TEM, 29(2), 69–71. https://doi.org/10.1016/j.tem.2017.12.003
2017:
Bert, B., Dörendahl, A., Leich, N., Vietze, J., Steinfath, M., Chmielewska, J., Hensel, A., Grune, B., & Schönfelder, G. (2017). Rethinking 3R strategies: Digging deeper into AnimalTestInfo promotes transparency in in vivo biomedical research. PLoS Biology, 15(12), e2003217. https://doi.org/10.1371/journal.pbio.2003217
Burgdorf, T., Dunst, S., Ertych, N., Fetz, V., Violet, N., Vogl, S., Schönfelder, G., Schwarz, F., & Oelgeschläger, M. (2017). The AOP Concept: How Novel Technologies Can Support Development of Adverse Outcome Pathways. Applied In Vitro Toxicology, 3(3), 271–277. https://doi.org/10.1089/aivt.2017.0011
Chmielewska, J., Bert, B., Grune, B., Hensel, A., & Schönfelder, G. (2017a). Probleme aus der tierversuchsrechtlichen Praxis: Rechtliche Einordnung der Genotypisierungsmethoden sowie der Zucht immunmodifizierter Tiere. Natur Und Recht, 39(6), 385–392. https://doi.org/10.1007/s10357-017-3190-4
Chmielewska, J., Bert, B., Grune, B., Hensel, A., & Schönfelder, G. (2017b). Rechtliche Probleme der Betäubung von Versuchstieren. Natur Und Recht, 39(8), 538–544. https://doi.org/10.1007/s10357-017-3212-2
Dahlhoff, M., Gaborit, N., Bultmann, S., Leonhardt, H., Yarden, Y., & Schneider, M. R. (2017). CRISPR-assisted receptor deletion reveals distinct roles for ERBB2 and ERBB3 in skin keratinocytes. The FEBS Journal, 284(19), 3339–3349. https://doi.org/10.1111/febs.14196
Herold, S., Krämer, D., Violet, N., & King, R. (2017). Rapid process synthesis supported by a unified modular software framework. Engineering in Life Sciences, 17(11), 1202–1214. https://doi.org/10.1002/elsc.201600020
Kodzius, R., Schulze, F., Gao, X., & Schneider, M. R. (2017). Organ-on-Chip Technology: Current State and Future Developments. Genes, 8(10). https://doi.org/10.3390/genes8100266
Schulze, F., Gao, X., Virzonis, D., Damiati, S., Schneider, M. R., & Kodzius, R. (2017). Air Quality Effects on Human Health and Approaches for Its Assessment through Microfluidic Chips. Genes, 8(10). https://doi.org/10.3390/genes8100244
Weidner, C., Steinfath, M., Wistorf, E., Oelgeschläger, M., Schneider, M. R., & Schönfelder, G. (2017). A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research. Journal of Visualized Experiments, 126, 55768. https://doi.org/10.3791/55768
2016:
Bert, B., Chmielewska, J., Bergmann, S., Busch, M., Driever, W., Finger?Baier, K., Hößler, J., Köhler, A., Leich, N., Misgeld, T., Nöldner, T., Reiher, A., Schartl, M., Seebach?Sproedt, A., Thumberger, T., Schönfelder, G., & Grune, B. (2016). Considerations for a European animal welfare standard to evaluate adverse phenotypes in teleost fish. The EMBO Journal, 35(11), 1151–1154. https://doi.org/10.15252/embj.201694448
Bert, B., Chmielewska, J., Hensel, A., Grune, B., & Schönfelder, G. (2016). The animal experimentation quandary: stuck between legislation and scientific freedom: More research and engagement by scientists is needed to help to improve animal welfare without hampering biomedical research. EMBO Reports, 17(6), 790–792. https://doi.org/10.15252/embr.201642354
Jungnickel, H., Pund, R., Tentschert, J., Reichardt, P., Laux, P., Harbach, H., & Luch, A. (2016). Time-of-flight secondary ion mass spectrometry (ToF-SIMS)-based analysis and imaging of polyethylene microplastics formation during sea surf simulation. The Science of the Total Environment, 563–564, 261–266. https://doi.org/10.1016/j.scitotenv.2016.04.025
Kugler, J., Kemler, R., Luch, A., & Oelgeschläger, M. (2016). Editor’s Highlight: Identification and Characterization of Teratogenic Chemicals Using Embryonic Stem Cells Isolated From a Wnt/β-Catenin-Reporter Transgenic Mouse Line. Toxicological Sciences, 152(2), 382–394. https://doi.org/10.1093/toxsci/kfw094
Kugler, J., Luch, A., & Oelgeschläger, M. (2016). Transgenic Mouse Models Transferred into the Test Tube: New Perspectives for Developmental Toxicity Testing In Vitro? Trends in Pharmacological Sciences, 37(10), 822–830. https://doi.org/10.1016/j.tips.2016.06.009
Raasch, M., Rennert, K., Jahn, T., Gärtner, C., Schönfelder, G., Huber, O., Seiler, A. E. M., & Mosig, A. S. (2016). An integrative microfluidically supported in vitro model of an endothelial barrier combined with cortical spheroids simulates effects of neuroinflammation in neocortex development. Biomicrofluidics, 10(4), 044102. https://doi.org/10.1063/1.4955184
Schlechtriem, C., Pucher, J., & Michalski, B. (2016). Dietary burden calculations relating to fish metabolism studies. Journal of the Science of Food and Agriculture, 96(5), 1415–1419. https://doi.org/10.1002/jsfa.7607
Weidner, C., Steinfath, M., Opitz, E., Oelgeschläger, M., & Schönfelder, G. (2016). Defining the optimal animal model for translational research using gene set enrichment analysis. EMBO Molecular Medicine, 8(8), 831–838. https://doi.org/10.15252/emmm.201506025
2015:
Chmielewska, J., Bert, B., Grune, B., Hensel, A., & Schönfelder, G. (2015). Der “vernünftige Grund” zur Tötung von überzähligen Tieren. Eine klassische Frage des Tierschutzrechts im Kontext der biomedizinischen Forschung. Natur Und Recht, 37(10), 677–682. https://doi.org/10.1007/s10357-015-2903-9
Riebeling, C., Fischer, K., Luch, A., & Seiler, A. E. M. (2015). Classification of reproductive toxicants with diverse mechanisms in the embryonic stem cell test. The Journal of Toxicological Sciences, 40(6), 809–815. https://doi.org/10.2131/jts.40.809
Schönfelder, G. (2015). Laboratory animals: German initiative opens up animal data. Nature, 519(7541), 33. https://doi.org/10.1038/519033d
Schönfelder, G., Grune, B., & Hensel, A. (2015). Animal welfare: Europe’s first “3Rs” governmental centre. Nature, 527(7576), 38. https://doi.org/10.1038/527038e
Smirnova, L., Seiler, A. E. M., & Luch, A. (2015). microRNA Profiling as Tool for Developmental Neurotoxicity Testing (DNT). Current Protocols in Toxicology, 64, 20.9.1-20.9.22. https://doi.org/10.1002/0471140856.tx2009s64
